What is the Origin of Human Longevity Science?

The discipline has roots in biogerontology, evolving significantly with advances in molecular biology, particularly in understanding conserved aging pathways like mTOR and sirtuins. "Longevity" emphasizes extended duration, while "science" denotes the rigorous, empirical approach to understanding the underlying mechanisms of successful aging phenotypes.

What is the Mechanism of Human Longevity Science?

Longevity mechanisms involve optimizing pathways that govern cellular maintenance and stress resistance. Key areas include promoting mitochondrial quality control through mitophagy, enhancing DNA repair mechanisms, and ensuring endocrine signaling remains youthful, particularly regarding insulin sensitivity and anabolic hormone sufficiency. Interventions often aim to mimic beneficial states induced by caloric restriction or periodic fasting to activate endogenous protective gene expression profiles.

Human Longevity Science

Meaning

Human Longevity Science is the interdisciplinary study focused on elucidating the fundamental biological processes underlying aging, with the goal of extending healthspan—the period of life spent in good health—rather than merely lifespan. This field heavily integrates endocrinology, genetics, and cellular senescence research to identify actionable targets. We seek to optimize the biological maintenance systems to promote robust function across the decades.