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Human Growth Hormone Pulsatility

Meaning

Human Growth Hormone Pulsatility refers to the characteristic pattern of Human Growth Hormone (HGH) secretion, which is not a continuous release but rather a series of distinct, intermittent bursts or pulses throughout the day and night. This pulsatile release pattern is crucial for HGH’s biological activity, as the magnitude and frequency of these pulses dictate the downstream production of Insulin-like Growth Factor-1 (IGF-1) and overall anabolic signaling. Clinically, preserving or restoring a robust pulsatile pattern is a primary goal for optimizing growth hormone function, which declines significantly with age.