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Hsp90

Meaning

Hsp90, or Heat Shock Protein 90, is a highly conserved, abundant molecular chaperone protein that is fundamentally essential for the correct folding, stabilization, and functional activity of a diverse array of client proteins, including several key steroid hormone receptors. This ATP-dependent enzyme plays a critical, protective role in maintaining cellular protein homeostasis, particularly under conditions of metabolic or environmental stress. In the field of endocrinology, its interaction with glucocorticoid, androgen, and estrogen receptors is indispensable for effective hormone signaling and overall cellular endocrine responsiveness.