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HSD3B1

Meaning

HSD3B1 refers to the gene that encodes the enzyme Hydroxysteroid 3-beta Dehydrogenase 1, a pivotal enzyme in the complex steroidogenesis pathway responsible for the synthesis of all major classes of steroid hormones, including glucocorticoids, mineralocorticoids, and sex steroids like testosterone and progesterone. This enzyme catalyzes an essential, early step in converting precursor steroids into their biologically active forms. Genetic polymorphisms within HSD3B1 can significantly influence an individual’s endogenous hormonal profile and disease risk.