What is the Meaning of hs-CRP?

hs-CRP, or high-sensitivity C-Reactive Protein, is a highly sensitive clinical biomarker used to measure low-grade, chronic systemic inflammation, which is often subclinical but a significant predictor of cardiovascular and metabolic risk. This acute-phase reactant is synthesized by the liver in response to inflammatory cytokines, such as interleukin-6, released by various tissues. In hormonal health, chronically elevated hs-CRP levels often correlate with insulin resistance, visceral obesity, and an increased risk of hormonal imbalance due to systemic inflammation.

What is the Origin of hs-CRP?

The term is an acronym for 'high-sensitivity C-Reactive Protein,' differentiating it from the standard CRP assay by its superior ability to accurately measure concentrations at the lower end of the clinical range. The protein itself was discovered in the 1930s, but the high-sensitivity assay became clinically relevant for cardiovascular risk stratification in the late 20th century. It is now a fundamental component of advanced preventative health panels, offering a quantitative measure of underlying inflammatory burden.

What is the Mechanism of hs-CRP?

C-Reactive Protein is an opsonin that plays a crucial role in the innate immune system, binding to phosphocholine on dead or damaged cells to facilitate their clearance by phagocytes. Its synthesis is rapidly and robustly induced by inflammatory cytokines released by activated immune cells, adipose tissue, and endothelial cells. The utility of the high-sensitivity measurement lies in its ability to detect the subtle, chronic inflammatory state that underlies many age-related and endocrine-related pathologies, providing a quantifiable target for anti-inflammatory interventions.

hs-CRP ∞ Area ∞ Library 4

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