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HRT Pharmacogenetics

Meaning

HRT Pharmacogenetics is the specialized field that studies how an individual’s genetic variations influence their response to Hormone Replacement Therapy (HRT), encompassing both efficacy and adverse effects. This clinical discipline focuses on genetic polymorphisms in genes encoding drug-metabolizing enzymes, hormone receptors, and transport proteins that interact with the exogenous hormones used in HRT. By analyzing a patient’s genetic profile, clinicians can predict their metabolic rate for specific hormone compounds and their tissue-specific receptor sensitivity, thereby allowing for a truly personalized selection of HRT compound, route of administration, and dosage.