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HPT Axis Recalibration

Meaning

HPT Axis Recalibration is the targeted clinical intervention aimed at restoring the optimal setpoint and function of the Hypothalamic-Pituitary-Thyroid axis, the primary regulatory system for metabolic rate and energy production. This involves addressing central (hypothalamic or pituitary) dysfunction and peripheral resistance, rather than solely treating isolated low thyroid hormone levels. The goal is to re-establish the precise negative feedback loop between Thyroid-Releasing Hormone (TRH), Thyroid-Stimulating Hormone (TSH), and the active thyroid hormones (T4 and T3). This is crucial for managing symptoms of fatigue, weight dysregulation, and cognitive decline.