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HPT Axis Interference

Meaning

HPT Axis Interference refers to any disruption or perturbation of the delicate feedback loop governing the Hypothalamic-Pituitary-Thyroid (HPT) axis, a critical endocrine pathway that regulates metabolism, energy expenditure, and cellular function throughout the body. This interference can stem from internal factors like autoimmune attack or pituitary dysfunction, or external factors such as endocrine-disrupting chemicals or chronic psychological stress that modulate the hypothalamic signaling. The clinical consequence is often thyroid hormone imbalance, leading to systemic metabolic and physiological derangements.