What is the Origin of HPS Axis Stimulation?

The term originates from neuroendocrinology, specifically the study of the growth hormone secretagogue system, which seeks to mimic or amplify the natural pulsatile release patterns of GH that diminish with age. Understanding the hypothalamic control of the pituitary gland forms the foundation of this therapeutic approach.

What is the Mechanism of HPS Axis Stimulation?

Stimulation is typically achieved through the administration of Growth Hormone-Releasing Hormones (GHRHs) or Growth Hormone Secretagogues (GHSs), which act on specific receptors in the pituitary somatotroph cells. This action promotes the synthesis and pulsatile release of GH into the systemic circulation, thereby enhancing tissue anabolism, metabolic regulation, and cellular regeneration.

HPS Axis Stimulation ∞ Area

HPS Axis Stimulation

Meaning

HPS Axis Stimulation refers to the clinical intervention designed to enhance the function of the Hypothalamic-Pituitary-Somatotropic axis, the neuroendocrine pathway responsible for the production and release of Growth Hormone (GH) and its downstream mediator, Insulin-like Growth Factor 1 (IGF-1). This stimulation is often pursued to support anabolic processes, cellular repair, and systemic metabolic health. The goal is to restore youthful pulsatility to the axis.