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HPS Axis Preservation

Meaning

HPS Axis Preservation refers to the clinical strategy of safeguarding the integrity and functional capacity of the Hypothalamic-Pituitary-Somatotropic (HPS) axis, the primary endocrine cascade responsible for regulating growth hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) secretion. Maintaining the health of this axis is vital for promoting anabolism, preserving lean body mass, supporting bone density, and regulating metabolism, particularly as GH secretion naturally declines with age. Preservation techniques aim to minimize suppression and maximize endogenous output.