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HPS Axis Dysregulation

Meaning

HPS Axis Dysregulation denotes an imbalance or disruption within a major hypothalamic-pituitary-target gland axis, often referring to the Hypothalamic-Pituitary-Steroidogenic axis, which governs the production of sex hormones or adrenal steroids. Dysregulation signifies an inappropriate, non-homeostatic pattern of hormone release or response, deviating from the normal rhythmic or feedback-controlled pattern. This functional disruption can lead to a cascade of systemic issues, including reproductive impairment, chronic stress response issues, or metabolic dysfunction. Restoring the harmonious communication along this central neuroendocrine pathway is a primary goal in hormonal health management.