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HPGAxisRegulation

Meaning

HPG Axis Regulation refers to the clinical and physiological control of the Hypothalamic-Pituitary-Gonadal axis, the master hormonal pathway responsible for governing reproductive function, sexual development, and the production of sex steroids like testosterone and estrogen. Optimal regulation ensures the pulsatile release of Gonadotropin-Releasing Hormone (GnRH) from the hypothalamus, leading to appropriate Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) secretion from the pituitary, which then stimulates the gonads. Precise regulation is essential for fertility, libido, bone health, and maintaining a healthy psychological state throughout life.