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HPGaxis

Meaning

The HPG axis, an abbreviation for the Hypothalamic-Pituitary-Gonadal axis, represents the critical neuroendocrine pathway that governs the development, regulation, and function of the reproductive system in both males and females. This intricate feedback loop involves the pulsatile release of Gonadotropin-Releasing Hormone (GnRH) from the hypothalamus, which stimulates the pituitary gland to secrete Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). These gonadotropins subsequently act on the gonads to produce sex steroids, such as testosterone and estrogen, essential for vitality and metabolic health.