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HPG Skeletal Axis

Meaning

The HPG Skeletal Axis represents the intricate regulatory feedback loop that connects the Hypothalamic-Pituitary-Gonadal (HPG) axis to bone metabolism and skeletal health. Sex hormones, primarily estrogens and androgens regulated by the HPG axis, are fundamental determinants of bone density and turnover throughout life. Clinically, understanding this connection is essential for managing conditions like osteoporosis that often arise from sex hormone deficiency.