Skip to main content

HPG Signaling Pathway

Meaning

The HPG Signaling Pathway, an abbreviation for the Hypothalamic-Pituitary-Gonadal axis, represents the critical neuroendocrine system that regulates the development, maturation, and reproductive function of the body throughout the lifespan. This interconnected pathway is responsible for the pulsatile release of sex hormones, including testosterone, estrogen, and progesterone, which govern fertility, secondary sexual characteristics, and metabolic health. It operates via a complex negative feedback loop to maintain hormonal homeostasis. Its proper function is essential for both reproductive and general systemic well-being.