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HPG Signaling Cascade

Meaning

The Hypothalamic-Pituitary-Gonadal (HPG) signaling cascade is the principal neuroendocrine axis responsible for the intricate regulation of reproductive function, sex steroid production, and gametogenesis in both male and female physiology. This intricate, hierarchical system operates through a tightly controlled, negative feedback loop that ensures the appropriate, rhythmic synthesis and release of hormones essential for fertility, sexual development, and the maintenance of secondary sexual characteristics. Disruptions anywhere within this critical cascade are the root cause of many hormonal imbalances and reproductive disorders.