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HPG Axis Understanding

Meaning

HPG Axis Understanding refers to the detailed clinical comprehension of the Hypothalamic-Pituitary-Gonadal axis, the crucial neuroendocrine feedback loop that governs reproductive and sexual maturation and function in both males and females. This understanding encompasses the pulsatile release of Gonadotropin-Releasing Hormone (GnRH) from the hypothalamus, the subsequent secretion of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) from the pituitary, and their final actions on the gonads to produce sex steroids and gametes. A deep clinical grasp of this axis is fundamental for diagnosing and treating hormonal imbalances related to fertility, menopause, and andropause.