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HPG Axis Synchronization

Meaning

The optimal, coordinated communication and regulatory rhythm between the Hypothalamus, Pituitary gland, and Gonadal glands, which collectively govern reproductive function, sexual development, and the production of sex steroids. Synchronization refers to the precise timing and amplitude of Gonadotropin-releasing hormone (GnRH), Luteinizing hormone (LH), and Follicle-stimulating hormone (FSH) secretion in response to feedback from gonadal hormones. Disruption of this synchronization is a primary cause of fertility issues and age-related hormonal decline, such as andropause and menopause.