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HPG Axis Substrate Support

Meaning

HPG Axis Substrate Support refers to the clinical strategy of ensuring an adequate and readily available supply of molecular precursors necessary for the optimal function of the Hypothalamic-Pituitary-Gonadal (HPG) axis. The HPG axis is the central neuroendocrine control system for reproductive and sexual hormone production, primarily utilizing cholesterol as its initial substrate. Effective substrate support ensures that the gonads have the raw materials to respond robustly to pituitary signaling, thus optimizing the synthesis of testosterone, estrogen, and progesterone. This approach is fundamental for addressing age-related or stress-induced declines in sex hormone output.