HPG Axis Signaling

Meaning

HPG Axis Signaling refers to the integrated communication pathway between the Hypothalamus, Pituitary gland, and Gonads (testes in males, ovaries in females), which is the central regulatory system for reproductive and sexual function. This hormonal axis dictates the production and release of key sex steroids, including testosterone, estradiol, and progesterone, controlling fertility, libido, and the maintenance of secondary sexual characteristics. Proper HPG axis signaling is crucial for maintaining endocrine homeostasis and is a primary target for fertility treatments and hormone modulation therapies. Its precise feedback loops are essential for physiological balance.

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