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HPG Axis Signaling Restoration

Meaning

HPG Axis Signaling Restoration is the therapeutic objective of re-establishing the proper communication and function within the Hypothalamic-Pituitary-Gonadal axis, the master endocrine system controlling reproductive and sexual hormone production. This restoration is typically sought after a period of suppression, such as following exogenous testosterone therapy, or to address certain forms of secondary hypogonadism. Successful restoration ensures the pulsatile release of gonadotropins and the subsequent return of natural sex steroid production.