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HPG Axis Signaling Assessment

Meaning

HPG Axis Signaling Assessment is the comprehensive clinical evaluation of the hypothalamic-pituitary-gonadal (HPG) axis, the primary neuroendocrine pathway regulating reproductive function, sex hormone production, and fertility. This assessment involves measuring the key regulatory hormones—Gonadotropin-Releasing Hormone (GnRH), Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), and the gonadal steroids—to pinpoint the exact locus of any hormonal dysfunction. Understanding the feedback loops within this axis is critical for diagnosing and managing conditions related to sexual health and aging. It provides a map of the central reproductive command.