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HPG Axis Restoration

Meaning

HPG Axis Restoration is a targeted clinical strategy designed to re-establish the endogenous, self-regulatory function of the Hypothalamic-Pituitary-Gonadal axis, which is frequently suppressed following the administration of exogenous sex steroids or compromised by certain pathological states. The primary objective is to encourage the pituitary to resume its pulsatile secretion of gonadotropins, thereby stimulating the gonads to synthesize physiological levels of testosterone or estrogen and resume gametogenesis. This process is crucial for long-term reproductive and endocrine health.