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HPG Axis Recalibration Strategies

Meaning

HPG Axis Recalibration Strategies are clinical and lifestyle interventions aimed at finely tuning the Hypothalamic-Pituitary-Gonadal axis, the primary endocrine system governing reproductive and sexual health. Recalibration involves restoring the appropriate pulsatile release of GnRH from the hypothalamus and the subsequent balanced secretion of LH and FSH from the pituitary, leading to optimized production of sex steroids like testosterone and estrogen from the gonads. These strategies are often employed to address functional hypogonadism, optimize fertility, or manage symptoms of perimenopause and andropause by improving the system’s central command. The goal is to achieve a youthful, responsive endocrine state.