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HPG Axis Re-Sensitization

Meaning

HPG Axis Re-Sensitization is a targeted clinical strategy aimed at restoring the optimal function and responsiveness of the Hypothalamic-Pituitary-Gonadal (HPG) axis. This neuroendocrine pathway controls reproductive and sexual function by regulating the production of sex hormones like testosterone and estrogen. Re-sensitization is necessary when the axis has become suppressed or desensitized, often due to chronic exogenous hormone use, aging, or prolonged stress. The primary goal is to encourage the body’s endogenous production of sex hormones by making the pituitary and gonads more responsive to central signals.