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HPG Axis Re-Engagement

Meaning

HPG Axis Re-Engagement is a specific clinical strategy aimed at stimulating and restoring the natural, endogenous function of the Hypothalamic-Pituitary-Gonadal (HPG) axis, which is the master hormonal pathway regulating reproductive and sexual health in both men and women. This strategy is employed when the axis has become suppressed or dysfunctional due to exogenous hormone use, chronic stress, aging, or other pathological factors. The goal is to encourage the hypothalamus and pituitary to resume the pulsatile release of Gonadotropin-Releasing Hormone (GnRH), Luteinizing Hormone (LH), and Follicle-Stimulating Hormone (FSH), thereby restoring natural gonadal hormone production. Re-engagement is a crucial step in fertility preservation and long-term endocrine health.