What is the Origin of HPG Axis Mapping?

The term is derived directly from classical endocrinology, where the HPG axis is a foundational concept. "Mapping" refers to the comprehensive, multi-point measurement and analysis required to understand the axis's dynamic function, rather than relying on single-point static measurements.

What is the Mechanism of HPG Axis Mapping?

The mechanism involves analyzing the pulsatile release patterns and the feedback sensitivity at each level of the axis: the hypothalamus, the pituitary gland, and the gonads. Dysfunction can occur at any point, such as primary gonadal failure or secondary hypothalamic/pituitary dysregulation. Precise mapping allows for targeted therapeutic interventions, such as selective receptor modulators or bioidentical hormone replacement, to restore rhythmic, homeostatic balance.

HPG Axis Mapping

Meaning

HPG Axis Mapping is a detailed clinical assessment of the Hypothalamic-Pituitary-Gonadal axis, the central neuroendocrine pathway regulating reproductive and sexual function, as well as influencing metabolism, bone density, and mood. This mapping involves measuring the complex feedback relationship between Gonadotropin-releasing hormone (GnRH), Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), and the peripheral sex steroids (e.g., testosterone, estrogen). It provides a precise diagnostic tool for identifying hormonal imbalances.