What is the Origin of HPG Axis Integrity Testing?

The HPG axis is a foundational concept in classical endocrinology, with its integrity testing protocols developing from early stimulation and suppression tests. The term 'integrity' emphasizes the functional interconnectedness of the three components, highlighting that a disruption at any level compromises the entire system's output.

What is the Mechanism of HPG Axis Integrity Testing?

The testing mechanism typically involves administering a known secretagogue, such as GnRH or a GnRH analog, and subsequently measuring the downstream hormonal responses, including Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), and sex steroids. The pattern of the resulting hormonal cascade reveals the specific site of dysfunction—hypothalamic, pituitary, or gonadal—by assessing the sensitivity and capacity of each gland in the axis.

HPG Axis Integrity Testing ∞ Area

HPG Axis Integrity Testing

Meaning

A specialized endocrine diagnostic procedure that evaluates the functional health and responsiveness of the Hypothalamic-Pituitary-Gonadal (HPG) axis, the primary neuroendocrine system controlling reproductive and sexual function. This testing assesses the coordinated communication between the hypothalamus, the pituitary gland, and the gonads. Integrity testing is essential for diagnosing central or primary hormonal insufficiencies and guiding appropriate restoration protocols.