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HPG Axis Inference

Meaning

HPG Axis Inference is the specialized clinical and analytical process of deducing the primary site and specific nature of a dysfunction within the Hypothalamic-Pituitary-Gonadal axis. This requires the critical interpretation of the relative patterns of measured hormones, including the inferred GnRH activity, the pituitary hormones LH and FSH, and the peripheral sex steroids like testosterone or estrogen. The goal is to accurately distinguish between primary gonadal failure, secondary pituitary failure, or tertiary hypothalamic dysfunction. This sophisticated inference is an essential step for accurately diagnosing and designing targeted treatments for reproductive and sex-hormone disorders.