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HPG Axis Function Maintenance

Meaning

HPG Axis Function Maintenance refers to the clinical and physiological strategies aimed at preserving the healthy, rhythmic signaling capacity of the Hypothalamic-Pituitary-Gonadal (HPG) axis, the central regulator of reproductive and sexual health. This axis, encompassing the hypothalamus, pituitary gland, and gonads (testes or ovaries), controls the pulsatile release of Gonadotropin-Releasing Hormone (GnRH), Luteinizing Hormone (LH), and Follicle-Stimulating Hormone (FSH), which in turn drive the production of sex steroids like testosterone and estrogen. Maintenance efforts are critical for supporting fertility, bone density, muscle mass, and libido throughout the lifespan. Disruptions can lead to hypogonadism or menopausal symptoms.