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HPG Axis Desynchronization

Meaning

HPG Axis Desynchronization describes a state where the coordinated pulsatile release and rhythmic feedback mechanisms within the Hypothalamic-Pituitary-Gonadal (HPG) axis are disrupted. This hormonal dysregulation impairs the proper signaling between the hypothalamus, which releases GnRH, the pituitary, which releases LH and FSH, and the gonads, which produce sex steroids like testosterone and estrogen. Desynchronization leads to sub-optimal sex hormone production, impacting fertility, mood, energy, and overall vitality. Clinical efforts often focus on restoring the natural, pulsatile rhythmicity of this axis.