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HPG Axis Cognitive Linkage

Meaning

HPG Axis Cognitive Linkage is the demonstrable and crucial neuroendocrine connection between the Hypothalamic-Pituitary-Gonadal (HPG) axis and specific, measurable domains of cognitive function, including declarative memory, executive control, and mood regulation. This profound linkage highlights the direct and indirect influence of sex hormones—primarily estrogens, progesterone, and testosterone—on the structural integrity and functional efficiency of the central nervous system. Clinical interventions often target this axis to mitigate cognitive symptoms associated with major hormonal transitions.