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HPA Axis Modulation Sleep

Meaning

HPA Axis Modulation Sleep refers to the regulatory influence that restorative sleep exerts on the Hypothalamic-Pituitary-Adrenal (HPA) axis, the body’s central stress response system. Clinically, adequate sleep is a non-negotiable factor for maintaining a healthy HPA axis, facilitating the necessary reduction in circulating cortisol levels and restoring sensitivity to the glucocorticoid negative feedback loop. This modulation is vital for preventing chronic stress-induced adrenal fatigue and systemic inflammation.