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HPA Axis Function Testing

Meaning

HPA Axis Function Testing is a diagnostic protocol used in clinical practice to evaluate the integrity and responsiveness of the Hypothalamic-Pituitary-Adrenal axis, the body’s central stress-response system. This testing typically involves collecting samples, such as saliva or blood, at multiple time points throughout the day to assess the diurnal rhythm of cortisol and often includes measurement of DHEA. The results provide a detailed physiological profile of the body’s adaptive capacity and help identify patterns of chronic stress-induced dysregulation, which is vital for personalized intervention planning. This assessment moves beyond static hormone levels to capture dynamic endocrine function.