What is the Origin of HPA Axis Epigenetic Reset?

This concept bridges the fields of stress physiology, endocrinology, and molecular biology, recognizing that chronic stress leaves a lasting molecular memory. The "reset" aspect implies a deliberate attempt to undo maladaptive epigenetic changes established during periods of high allostatic load.

What is the Mechanism of HPA Axis Epigenetic Reset?

The mechanism focuses on reversing specific epigenetic marks, such as aberrant DNA methylation at the glucocorticoid receptor gene in the hippocampus or CRH gene in the hypothalamus. By normalizing these marks, the axis regains its appropriate sensitivity to circulating cortisol, thereby reinstating robust negative feedback and returning the diurnal cortisol profile to a healthy, balanced rhythm.

HPA Axis Epigenetic Reset ∞ Area

HPA Axis Epigenetic Reset

Meaning

HPA Axis Epigenetic Reset is a targeted intervention designed to normalize the chronic stress programming imprinted on the Hypothalamic-Pituitary-Adrenal axis through molecular reprogramming. This process seeks to reverse the long-term epigenetic alterations induced by sustained psychological or physiological stressors. We aim to restore the axis’s appropriate sensitivity and feedback control.