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HPA Axis Dysregulation

Meaning

HPA Axis Dysregulation describes a state where the Hypothalamic-Pituitary-Adrenal axis fails to appropriately manage the body’s response to stress, leading to pathological cortisol secretion patterns. This imbalance can manifest as chronic hypercortisolism or hypocortisolism, profoundly affecting metabolism and immunity. Sustained dysregulation is a common sequela of chronic psychological or physiological strain.