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HPA Axis Dysregulation

Meaning

HPA axis dysregulation describes a state where the normal, rhythmic communication and feedback loops within the Hypothalamic-Pituitary-Adrenal axis are compromised, leading to an inappropriate or altered release of glucocorticoids, particularly cortisol. This condition is not a failure of the axis but rather an adaptive shift in its set point, often in response to chronic psychological or physiological stress. The resulting imbalance can manifest as symptoms ranging from chronic fatigue and sleep disturbances to immune system alterations and hormonal shifts. Clinical assessment requires careful measurement of cortisol and DHEA patterns throughout the day.