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HPA Axis Dysregulation Cortisol

Meaning

HPA Axis Dysregulation Cortisol describes the pathological condition where the Hypothalamic-Pituitary-Adrenal (HPA) axis, the body’s central stress response system, exhibits an abnormal pattern of cortisol secretion. This dysregulation can manifest as hypercortisolemia, hypocortisolemia, or a flattened diurnal rhythm, all deviating from the healthy, robust pattern. It is a key clinical marker of chronic stress, allostatic load, and various endocrine-related pathologies. Clinically addressing this dysregulation is paramount for restoring metabolic, immune, and psychological health.