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HPA Axis Dysfunction Markers

Meaning

HPA Axis Dysfunction Markers are measurable physiological or biochemical indicators that signal a disruption in the delicate regulatory feedback loop of the Hypothalamic-Pituitary-Adrenal (HPA) axis, the body’s central stress response system. These biomarkers extend beyond simple cortisol measurements and include alterations in the cortisol diurnal rhythm, shifts in the cortisol-to-DHEA ratio, or aberrant levels of upstream signaling molecules like ACTH. Identifying these markers is crucial for diagnosing chronic stress-related endocrine imbalances that affect mood, metabolism, and immunity.