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HPA Axis Dynamic Range

Meaning

The HPA Axis Dynamic Range represents the full physiological capacity of the Hypothalamic-Pituitary-Adrenal axis to respond to stress, spanning from its minimal basal output to its maximum stress-induced secretory peak. A healthy, wide dynamic range signifies a resilient stress system capable of mounting a rapid, robust cortisol response when necessary and quickly returning to baseline once the stressor is removed. Conversely, a restricted or flattened range, often seen in chronic stress or fatigue states, indicates impaired hormonal adaptability and diminished reserve. Maintaining an optimal dynamic range is paramount for metabolic health, immune function, and psychological well-being.