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HPA Axis Digital Biomarkers

Meaning

HPA Axis Digital Biomarkers are quantifiable, objective physiological metrics collected via non-invasive digital devices, such as smart rings or continuous glucose monitors, that serve as proxies for the activity and regulation of the Hypothalamic-Pituitary-Adrenal axis. These markers include heart rate variability (HRV), resting heart rate, sleep architecture patterns, and certain activity metrics, which collectively reflect the body’s allostatic load and stress response. The clinical utility lies in providing a longitudinal, real-time assessment of stress resilience and chronic HPA axis dysregulation without the need for frequent invasive lab draws.