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HPA Axis Communication

Meaning

HPA Axis Communication refers to the intricate, hierarchical, and bidirectional signaling network linking the Hypothalamus, Pituitary gland, and Adrenal glands, which serves as the body’s master regulator of the stress response and energy metabolism. This crucial neuroendocrine cascade involves the sequential release of Corticotropin-Releasing Hormone (CRH), Adrenocorticotropic Hormone (ACTH), and finally, cortisol. Robust and precise communication across this axis is absolutely vital for maintaining systemic resilience and preventing the chronic pathology associated with maladaptive stress responses.