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HPA Axis Adjustment

Meaning

HPA Axis Adjustment is a therapeutic strategy aimed at modulating the activity of the Hypothalamic-Pituitary-Adrenal (HPA) axis, which is the body’s central neuroendocrine system governing the stress response and maintaining systemic homeostasis. Adjustment seeks to correct chronic hyper- or hypo-activation, often associated with sustained psychological or physiological stress, by restoring the appropriate feedback sensitivity. Successful adjustment is key to improving energy, sleep, and overall physiological resilience.