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Host-Microbe Co-Regulation

Meaning

Host-Microbe Co-Regulation describes the intricate, bidirectional communication and mutual influence between the human host and its commensal microbial communities, primarily residing in the gut. This symbiotic relationship extends beyond digestion, critically influencing immune system development, neurotransmitter production, and the metabolism of endogenous and exogenous compounds. This co-regulation is a cornerstone of systemic health, as microbial metabolites directly impact host endocrine signaling and metabolic processes. Disruption of this balance, known as dysbiosis, is a significant contributor to chronic inflammatory and hormonal disorders.