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Host Metabolic Programming

Meaning

Host Metabolic Programming is the concept that the body’s fundamental metabolic and hormonal set points, including insulin sensitivity, fat storage propensity, and energy expenditure, are established and permanently influenced by early life environmental exposures, particularly nutrition and the maternal and infant microbiome. This programming dictates an individual’s long-term risk profile for developing chronic metabolic and endocrine diseases later in life. Understanding these programmed pathways allows for targeted interventions to mitigate inherited vulnerabilities.