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Horvath Clock

Meaning

The Horvath Clock is a specific, highly accurate epigenetic clock, a mathematical model that estimates an individual’s biological age by analyzing the methylation status of specific CpG sites across the human genome. This tool is clinically significant as a biomarker of aging, providing a quantitative measure of ‘epigenetic age’ that often deviates from chronological age, reflecting cumulative lifestyle and environmental damage. The clock’s output, known as age acceleration, is a powerful predictor of morbidity and all-cause mortality.