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Hormone-Sensitive Lipase

Meaning

Hormone-Sensitive Lipase (HSL) is a cytosolic enzyme predominantly expressed in adipose tissue that catalyzes the hydrolysis of stored triglycerides into free fatty acids and glycerol, a process known as lipolysis. This enzyme’s activity is highly regulated by various hormonal signals, making it a central mediator in the body’s energy mobilization and utilization pathways. It is crucial for providing energy substrates during periods of fasting or increased metabolic demand.