The meticulous, data-driven customization of exogenous hormone administration, encompassing dose, timing, route, and compound selection, to mimic physiological hormone dynamics as closely as possible for an individual patient. It moves beyond standardized dosing protocols.
Origin
This concept evolves from traditional hormone replacement therapy (HRT) by incorporating advanced diagnostics and chronobiology principles to achieve superior therapeutic windows. Precision emphasizes individualized pharmacokinetics and pharmacodynamics.
Mechanism
Precision is achieved by titrating replacement doses based on serial monitoring of hormone metabolites and receptor response indicators, rather than just trough levels. The strategy aims to restore the correct amplitude and rhythm of hormonal signaling to maintain target tissue function without inducing supra-physiological states.
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