Hormone Replacement Optimization is the systematic, data-driven refinement of exogenous hormone administration to achieve specific physiological endpoints mirroring optimal endogenous function across the lifespan. This process demands continuous monitoring of symptomology alongside serum or salivary hormone levels to fine-tune dosage, timing, and delivery method. The goal transcends simple replacement toward maximizing functional capacity.
Origin
This term merges “Hormone Replacement,” referring to therapeutic substitution, with “Optimization,” derived from the Latin optimus (best), indicating a pursuit of the highest functional standard. It represents an evolution from historical replacement therapy paradigms.
Mechanism
Optimization involves kinetic modeling of exogenous compounds to match the body’s natural secretory rhythms, such as mimicking nocturnal pulses or diurnal variations of cortisol. Adjustments are made based on feedback mechanisms, ensuring that receptor occupancy is appropriate without inducing supra-physiological states that could trigger negative feedback loops on the HPTA or HPA axes.
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