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Hormone Replacement Dosing Frequency

Meaning

Hormone Replacement Dosing Frequency is the clinically determined schedule by which exogenous hormones are administered, a critical factor influencing the pharmacokinetic profile and physiological efficacy of the therapy. The frequency of dosing must be strategically selected to closely mimic the body’s natural pulsatile or diurnal secretion patterns, aiming to maintain stable, physiological serum concentrations without inducing supraphysiological peaks or trough levels. Inadequate frequency can lead to fluctuations that increase side effects and diminish therapeutic benefit.